Our Safety Pharmacology group profiles compounds for potential adverse drug reactions at various R&D stages, thereby helping to deliver high-quality drug candidates faster and at lower cost.
Identify off-target based adverse drug reactions (ADR) at early stage of drug discovery. Such information may help guide compounds of interest through downstream in vivo tests for potential liabilities, and reduce attrition of drug candidates and even withdrawal of approved drugs.
Led by a group of experienced scientists in drug discovery, safety panel team offers in vitro mini-Safety Panel Service for early pharmacological profiling of off-target and adverse effects of lead compounds or PCCs in drug development stage. Data are also useful for drug candidate SAR design. Assay targets in the panel are selected to form a minimal panel, recommended by scientists from four major pharmaceutical companies, to provide broad and diverse early in vitro safety assessments of testing compounds. Compounds can be screened by radioligand binding, biochemical and/or functional assays.