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IBS/IBD animal models

Overview

Inflammatory bowel disease (IBD) is an autoimmune disease caused by a dysregulated immune response to host intestinal microbiota. There are two major types of IBD: ulcerative colitis (UC) and Crohn’s disease (CD). Irritable bowel syndrome (IBS) is a condition that produces similar symptoms to those of IBD but without GI tract inflammation. More than 5 million population live with a form of IBD and 0.7 billion people suffer with IBS. Currently there is no well-developed cure for IBD or IBS. As part of WuXi Research Service Division (RSD), the Biology Unit, led by a group of leading scientists with significant experience in drug discovery, has fully developed IBD/IBS animal models for new compound development for both IBD and IBS.

 

WuXi AppTec IBD/IBS Models

The following models of IBD/IBS are available at WuXi:

  • DSS-Induced IBD: Acute
  • DSS-Induced IBD: Chronic
  • TNBS-Induced IBD
  • T Cell Transfer Model of Colitis
  • Telemetry Irritable bowel syndrome (IBS) model

 

Deliverables:

  • Time course of body weight change
  • Disease scores, organ length and weight
  • Blood biochemical analysis, including white cells and interleukins etc.
  • Histopathology scoring of collected tissue
  • Telemetry EMG signaling and analysis for IBS

 

A Custom Protocol is designed for a study to meet Sponsor’s requirements.

 

Figure 1. Cyclosporin A effects in IBD model

 

Figure 2. Tegaserod effects on EMG in IBS model