WuXi AppTec HitS Unit provides a one-stop Target-to-Hit services that enable companies in the pharmaceuticals, biotech and academics worldwide to seek premium drug discovery. As an innovation-driven and customer-focused unit, HitS helps our partners to improve the productivity of advancing hit discovery through high-quality and cost-effective solutions. With industry-leading capabilities such as protein science, biophysics, DNA-encoded library technology, and structure-based drug design, HitS is committed to drive toward the realization of the vision that every drug can be made and every disease can be treated.
Empowered by the HitS platform, our partners can start with an idea in mind and be provided with a high quality, one-stop solution that gives a validated hit with clear MOA for the following hit-to-lead research.
An Integrated Target-to-Hit Platform
The comprehensive evaluation of the target protein and their down-stream applications would be set as the start point. The construct is then designed and precisely tailored towards the following screening or biophysical assay. Target proteins are produced with our highly parallelized expression and purification platform. Taking advantages of our proprietary tools and expression vectors, we are able to produce complexes and even virus-like particles with one single vector. With the help of our in house state-of-the-art biophysics platform, comprehensive protein QC can be performed on aspects including stability, folding, aggregation and post-translational modifications.
DNA-Encoded Library Technology
HitS provides customers with a cutting-edge hit identification and optimization platform using an affinity-based selection method against DNA-encoded small molecule libraries.
Fragment Based Screening (FBDD)
HitS offers fast and cost-efficient hit identification by fragment screening. We have several well-tended fragment libraries totaling more than 3,100 compounds. In addition, client libraries can easily be integrated in our workflow.
Biophysical & Biochemical Platform
HitS has established a number of biophysical and biochemical assays and methods which can be combined according to the needs of a specific project.
Structure-Based Drug Discovery
HitS has comprehensive structural generation solutions for today´s challenging targets provide insights and data to support hit finding through to lead optimization.